SkinCeuticals AGE Interrupter Advanced

Is SkinCeuticals AGE Interrupter Advanced right for you?

• If you have deep wrinkles, particularly around the mouth, forehead, or nasolabial folds — this is a targeted corrective moisturiser formulated specifically for established, deep-set lines.
• If your skin has lost significant density and elasticity in your 40s or beyond — the Proxylane complex restores the dermal matrix components that underpin firmness and volume.
• If you want a moisturiser that actively treats as well as hydrates — AGE Interrupter Advanced replaces a basic night cream with clinically meaningful corrective action.
• If you are using in-clinic anti-ageing treatments like RF, laser, or fillers — this cream complements and maintains those results between sessions.
• If you have dry to normal skin that needs a rich moisturiser alongside active treatment — the cream texture provides substantial barrier support alongside its corrective actives.

How SkinCeuticals AGE Interrupter Advanced works — the science

AGE Interrupter Advanced is centred on Proxylane (XYLOSE) — a patented active derived from xylose (a wood sugar) that stimulates fibroblast activity in the dermis. Specifically, it upregulates the synthesis of glycosaminoglycans (GAGs) — the molecular scaffold that gives youthful dermis its density, bounce, and hydration. As GAG production declines with age (accelerating after 40), the dermis becomes thinner and less capable of supporting the overlying skin, leading to the sagging and deep lines that characterise mature skin. Proxylane directly addresses this root cause.

Niacinamide (Vitamin B3) provides multiple complementary benefits: it inhibits the transfer of melanosomes (reducing pigmentation), strengthens the skin barrier, reduces transepidermal water loss, and has an anti-inflammatory effect that improves overall skin quality. Together, Proxylane and Niacinamide address the structural, hydration, and tone dimensions of facial ageing in a single rich moisturiser.

What you will notice — and when

Immediately — Rich, comfortable hydration; skin feels substantially more supple and nourished after the first application.

Week 1–2 — Deep lines appear softened; skin feels denser and more elastic.

Month 1+ — Measurable reduction in the depth of nasolabial folds and forehead lines; skin tone more even; significant improvement in skin density and overall firmness.

How to use SkinCeuticals AGE Interrupter Advanced

1. Apply morning and/or evening as your moisturising step after serums.
2. Warm a small amount between fingertips and press gently across face and neck.
3. Pay particular attention to areas of deep wrinkling — nasolabial folds, marionette lines, forehead.
4. At night, apply more generously as an overnight treatment.
5. Do not use in the eye area — use AGE Eye Complex for periorbital concerns.

Key ingredients & what they do

Ingredient	What it does for you
Proxylane (30%)	Stimulates dermal glycosaminoglycan synthesis — restores the molecular scaffolding that gives skin its density, volume, and bounce
Niacinamide (Vitamin B3)	Reduces pigmentation transfer, strengthens the barrier, reduces water loss, and improves overall skin tone and radiance
Rich moisturising base	Deeply hydrates the dermis and epidermis — appropriate for dry to normal skin types requiring substantial moisture alongside active treatment

Dr. Bangalee's clinical perspective

Dr. Bangalee Recommends

"AGE Interrupter Advanced is my recommendation for patients with established deep wrinkles who want topical support between clinic visits. The Proxylane concentration is meaningful and the clinical data on glycosaminoglycan stimulation is solid. I often prescribe this alongside filler treatments — when we restore volume with hyaluronic acid filler, this cream helps maintain the tissue quality around the treated area. The niacinamide component also addresses the uneven tone that typically accompanies mature skin."

Dr. Rajeev Bangalee MBBch · HPCSA Reg. MP 0558605 Star Aesthetic Centre

What our patients say

"I'm 58 and have been using this for four months. The deep lines around my mouth have genuinely softened — my husband noticed before I even pointed it out to him." Beverley, Kloof	"Dr. B recommended this to complement my filler treatment and I think it makes a real difference in how long my results last between appointments." Sunita, Umhlanga	"Rich, luxurious texture and my skin wakes up looking noticeably smoother and firmer. I've tried many night creams but nothing has worked like this." Elaine, Morningside

Frequently asked questions

Question	Answer
Can I use it morning and evening?	Yes — it is formulated for twice-daily use. Many patients apply a lighter layer in the morning and a more generous layer at night.
Is it too heavy for oily skin?	The rich cream texture is best suited to dry or normal skin. Oily skin types may find it too heavy — consult your practitioner for an alternative.
Can I use it with my retinol?	Yes — apply retinol first, wait for it to absorb, then apply AGE Interrupter Advanced as a moisturising layer.
How long before I see results on deep wrinkles?	Deep, established wrinkles take longer to respond than surface lines. Most patients see meaningful improvement at 8–12 weeks. Results continue to improve with ongoing use.
Is it safe during pregnancy?	Proxylane and niacinamide are generally considered safe, but consult your obstetrician before use during pregnancy.